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Off The MapOff the Map is a Medical drama created by Jenna Bans, who also serves as an executive producer, with colleagues from Grey's Anatomy, Shonda Rhimes and Betsy Beers.  It premiered on ABC on January 12, 2011, with 13 episodes ordered.

The series is set in a remote South American village, where seven doctors search for reasons that brought each of them to medicine.

Martin Henderson as Dr.  Ben Keeton - Keeton is "one of the world's greatest humanitarians," according to Mina and Lily.  It is hinted that he was formerly involved with Ryan Clark, but he says in the second episode that keeping it professional is "not completely his choice." Ryan tells him at the cantina that she knows that he's developing feelings for Lily by the way he looks at her, which is how he used to look at Ryan.  He has since seen Lily naked while she was bathing under a waterfall.  Ryan told Lily at the end of "A Doctor Time Out" that Ben lost his wife, Abby, and their child in an accident.  In episode 4 it's revealed that Abby is on life support in the San Miguel Hospital and Ben is keeping her on life support because her trust fund bankrolls the clinic.

Jason Winston George as Dr.  Otis Cole - It is said about Cole that his bark is "just as bad as his bite." Although he is strict while working, off the job he can be extremely silly.  He is currently developing a relationship with Zee.  He used to be addicted to morphine and heroin and consumes candy to help stay clean.  He contemplates relapsing at the end of "It's Good".  It is suggested he has feelings for Mina.
Valerie Cruz as Zitajalehrena Alverez (Zee) - Zee is the mother hen of the doctors.  She shows disapproval towards workplace romances but has developed a relationship with Cole.

Caroline Dhavernas as Dr.  Lily Brenner - Brenner's fiancé was killed in a cycling accident after she asked him to go out and get her some cereal.  She has an attraction to Ben Keeton, although this was set back by her disapproval at his handling of a patient in "A Doctor Time Out".  She now has a relationship with Mateo, a farmer.  She has had two similar experiences with men she is attracted to in a waterfall.

Zach Gilford as Dr.  Tommy Fuller - Tommy is shown to be a promiscuous and light-hearted character who incurred Cole's wrath quite early on, earning the nickname "Plastics." He is shown to have "barely made his way through medical school" according to Cole.  Tommy also has a crush on Ryan.  He was dating Alma, who's father owns the cantina.

Mamie Gummer as Dr.  Mina Minard - Mina is a doctor who "only works solo" and loses confidence easily due to a misdiagnosis earlier in her career that led to the death of a patient.  She is highly competitive at work.  She owns a chicken named Dinner that was given to her by a grateful patient.  The patient whom she misdiagnosed was a boy named Eric.  In episode 4 Mina says that her father is the head of a major Boston hospital, and when she misdiagnosed Eric he wiped her resume clean of the incident.  She appears to have some kind of attraction to Cole.  In episode 8, Mina sleeps with Tommy while she is drunk after a party for her new god-daughter.

Rachelle Lefevre as Dr.  Ryan Clark - Ryan's parents were missionaries, and she implies that she is religious.  She is in a on again-off again relationship with Ben that starts the series off and by episode 4 their relationship is back on.  Ryan was bitten by an assassin bug in El Salvador when she was eight years old which went untreated causing her to develop Chagas Disease.  Twenty years later and the disease has caused irreversible heart damage.  At the end of episode 7 Ben's scan reveals that Ryan is in heart failure.  Seeing the worry on Ben's face leads Ryan to finally say "I love you".

Jonathan Castellanos as Charlie - When Charlie was 9, his parents abandoned him.  He now works at the clinic, and "supposedly" lives in a hostel.  It is shown that he actually house-sits condos for 6 months a year, and has a bed under a lab in the clinic as well.  He is good friends with both Tommy and Cole.  Charlie has a crush on Brenner and was worried that she didn't know his name.  Charlie has given voice to the titles of episode 3 and 4.

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